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Glycobiology. 2019 Aug 14. pii: cwz062. doi: 10.1093/glycob/cwz062. [Epub ahead of print]

9-O-acetyl sialic acid levels identify committed progenitors of plasmacytoid dendritic cells.

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Ragon Institute of MGH, MIT and Harvard and The MGH Cancer Center Massachusetts General Hospital, Harvard Medical School Cambridge, MA 02139.
Dana-Farber Cancer Institute, Pediatric Oncology, Harvard Medical School, Boston, MA 02115.
Division of Rheumatology, Faculté de médecine et des sciences de la santé de l' Université deSherbrooke et Centre de Recherche Clinique Étienne-Le Bel, Sherbrooke, Québec, Canada.


The origins of plasmacytoid dendritic cells have long been controversial and progenitors exclusively committed to this lineage have not been described. We show here that the fate of hematopoietic progenitors is determined in part by their surface levels of 9-O-acetyl sialic acid. Pro-plasmacytoid dendritic cells were identified as lineage negative 9-O-acetyl sialic acid low progenitors that lack myeloid and lymphoid potential but differentiate into pre-plasmacytoid dendritic cells. The latter cells are also lineage negative, 9-O-acetyl sialic acid low cells but are exclusively committed to the plasmacytoid dendritic cell lineage. Levels of 9-O-acetyl sialic acid provide a distinct way to define progenitors and thus facilitate the study of hematopoietic differentiation.


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