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Glycobiology. 2019 Nov 20;29(12):861-875. doi: 10.1093/glycob/cwz062.

9-O-acetyl sialic acid levels identify committed progenitors of plasmacytoid dendritic cells.

Author information

1
Ragon Institute of MGH, MIT and Harvard, Cambridge MA 02139 and The MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
2
Dana-Farber Cancer Institute, Pediatric Oncology, Harvard Medical School, Boston, MA 02115, USA.
3
Division of Rheumatology, Faculté de Médecine et des Sciences de la Santé de l', Université de Sherbrooke et Centre de Recherche Clinique Étienne-Le Bel, Sherbrooke, Québec, Canada, J1K 2R1.

Abstract

The origins of plasmacytoid dendritic cells (pDCs) have long been controversial and progenitors exclusively committed to this lineage have not been described. We show here that the fate of hematopoietic progenitors is determined in part by their surface levels of 9-O-acetyl sialic acid. Pro-pDCs were identified as lineage negative 9-O-acetyl sialic acid low progenitors that lack myeloid and lymphoid potential but differentiate into pre-pDCs. The latter cells are also lineage negative, 9-O-acetyl sialic acid low cells but are exclusively committed to the pDC lineage. Levels of 9-O-acetyl sialic acid provide a distinct way to define progenitors and thus facilitate the study of hematopoietic differentiation.

KEYWORDS:

9-O-acetyl sialic acid; hematopietic progenitors; plasmacytoid dendritic cells

PMID:
31411667
PMCID:
PMC6861835
[Available on 2020-05-17]
DOI:
10.1093/glycob/cwz062

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