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Indian J Med Res. 2019 Apr;149(4):548-553. doi: 10.4103/ijmr.IJMR_916_18.

Geographical distribution of primary & secondary dengue cases in India - 2017: A cross-sectional multicentric study.

Author information

1
Manipal Centre for Virus Research, Manipal Academy of Higher Education (Deemed to be University), Manipal, India.
2
Indian Council of Medical Research, Department of Health Research, Ministry of Health & Family Welfare, Government of India, Bengaluru, India.
3
Department of Microbiology, Bangalore Medical College and Research Institute, Bengaluru, India.
4
Department of Microbiology, King George's Medical University, Lucknow, India.
5
Department of Microbiology, All India Institute of Medical Sciences, Bhopal, India.
6
ICMR-Regional Medical Research Centre, Bhubaneshwar, India.
7
Department of Microbiology, Sawai Man Singh Medical College and Attached Hospitals, Jaipur, India.
8
Department of Microbiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India.
9
ICMR-National Institute of Malaria Research, New Delhi, India.
10
Department of Microbiology, Government Theni Medical College, Theni, India.
11
Department of Microbiology, Government Medical College, Amritsar, India.
12
Department of Microbiology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
13
National Institute for Research in Tribal Health, Jabalpur, India.
14
ICMR-National Institute of Cholera & Enteric Diseases, Kolkata, India.
15
Department of Virology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
16
ICMR-Regional Medical Research Centre, Port Blair, India.
17
ICMR-Regional Medical Research Centre, North East Region, Dibrugarh, India.
18
Department of Microbiology, Jorhat Medical College, Jorhat, India.
19
Department of Microbiology, Agartala Government Medical College, Agartala, India.

Abstract

Background & objectives:

Dengue virus infection is endemic in India with all the four serotypes of dengue virus in circulation. This study was aimed to determine the geographic distribution of the primary and secondary dengue cases in India.

Methods:

A multicentre cross-sectional study was conducted at Department of Health Research / Indian Council of Medical Research (DHR)/(ICMR) viral research and diagnostic laboratories (VRDLs) and selected ICMR institutes located in India. Only laboratory-confirmed dengue cases with date of onset of illness less than or equal to seven days were included between September and October 2017. Dengue NS1 antigen ELISA and anti-dengue IgM capture ELISA were used to diagnose dengue cases while anti-dengue IgG capture ELISA was used for identifying the secondary dengue cases.

Results:

Of the 1372 dengue cases, 897 (65%) were classified as primary dengue and 475 (35%) as secondary dengue cases. However, the proportion varied widely geographically, with Theni, Tamil Nadu; Tirupati, Andhra Pradesh and Udupi-Manipal, Karnataka reporting more than 65 per cent secondary dengue cases while Srinagar, Jammu and Kashmir reporting as low as 10 per cent of the same. The median age of primary dengue cases was 25 yr [interquartile range (IQR 17-35] while that of secondary dengue cases was 23 yr (IQR 13.5-34). Secondary dengue was around 50 per cent among the children belonging to the age group 6-10 yr while it ranged between 20-43 per cent among other age groups.

Interpretation & conclusions:

Our findings showed a wide geographical variation in the distribution of primary and secondary dengue cases in India. It would prove beneficial to include primary and secondary dengue differentiation protocol in the national dengue surveillance programme.

KEYWORDS:

Dengue; India; geographic variation; primary; secondary; viral research and diagnostic laboratories

PMID:
31411180
PMCID:
PMC6676848
DOI:
10.4103/ijmr.IJMR_916_18
[Indexed for MEDLINE]
Free PMC Article

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