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BJOG. 2019 Oct;126(11):1310-1319. doi: 10.1111/1471-0528.15863. Epub 2019 Aug 13.

Human uterine transplantation: a review of outcomes from the first 45 cases.

Author information

1
Hammersmith Hospital, Imperial College NHS Trust London, London, UK.
2
Imperial College London, London, UK.
3
Lister Fertility Clinic, The Lister Hospital, London, UK.
4
Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
5
IVI London, IVIRMA Global, London, UK.
6
The Oxford Transplant Centre, The Churchill Hospital, Oxford University Hospitals NHS Trust, Oxford, UK.
7
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
8
Baylor University Medical Center, Dallas, TX, USA.

Abstract

Uterine transplantation restores reproductive anatomy in women with absolute uterine factor infertility and allows the opportunity to conceive, experience gestation, and acquire motherhood. The number of cases being performed is increasing exponentially, with detailed outcomes from 45 cases, including nine live births, now available. In light of the data presented herein, including detailed surgical, immunosuppressive and obstetric outcomes, the feasibility of uterine transplantation is now difficult to refute. However, it is associated with significant risk with more than one-quarter of grafts removed because of complications, and one in ten donors suffering complications requiring surgical repair. TWEETABLE ABSTRACT: Uterine transplantation is feasible in women with uterine factor infertility, but is associated with significant risk of complication.

KEYWORDS:

Gynaecology; Mayer-Rokitansky-Küster-Hauser syndrome; immunology; infertility; pregnancy; transplantation; uterus

PMID:
31410987
DOI:
10.1111/1471-0528.15863
[Indexed for MEDLINE]

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