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Nat Commun. 2019 Aug 13;10(1):3653. doi: 10.1038/s41467-019-11451-y.

GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits.

Author information

1
MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary's campus, Norfolk Place, London, W2 1PG, UK.
2
Department of Hygiene and Epidemiology, University of Ioannina Medical School, 45110, Ioannina, Greece.
3
Dementia Research Institute at Imperial College London, London, W2 1PG, UK.
4
NIHR Imperial Biomedical Research Centre, ITMAT Data Science Group, Imperial College London, London, W2 1PG, UK.
5
Department of Stroke Medicine, Imperial College London, London, W2 1PG, UK.
6
Imperial College NIHR Biomedical Research Centre, London, W2 1NY, UK.
7
Health Data Research UK-London, London, NW1 2BE, UK.
8
MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary's campus, Norfolk Place, London, W2 1PG, UK. i.tzoulaki@imperial.ac.uk.
9
Department of Hygiene and Epidemiology, University of Ioannina Medical School, 45110, Ioannina, Greece. i.tzoulaki@imperial.ac.uk.
10
Dementia Research Institute at Imperial College London, London, W2 1PG, UK. i.tzoulaki@imperial.ac.uk.
11
MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary's campus, Norfolk Place, London, W2 1PG, UK. a.dehghan@imperial.ac.uk.
12
Dementia Research Institute at Imperial College London, London, W2 1PG, UK. a.dehghan@imperial.ac.uk.

Abstract

Urinary sodium and potassium excretion are associated with blood pressure (BP) and cardiovascular disease (CVD). The exact biological link between these traits is yet to be elucidated. Here, we identify 50 loci for sodium and 13 for potassium excretion in a large-scale genome-wide association study (GWAS) on urinary sodium and potassium excretion using data from 446,237 individuals of European descent from the UK Biobank study. We extensively interrogate the results using multiple analyses such as Mendelian randomization, functional assessment, co localization, genetic risk score, and pathway analyses. We identify a shared genetic component between urinary sodium and potassium expression and cardiovascular traits. Ingenuity pathway analysis shows that urinary sodium and potassium excretion loci are over-represented in behavioural response to stimuli. Our study highlights pathways that are shared between urinary sodium and potassium excretion and cardiovascular traits.

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