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Sci Data. 2019 Aug 13;6(1):148. doi: 10.1038/s41597-019-0154-y.

DRAMP 2.0, an updated data repository of antimicrobial peptides.

Author information

1
School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211100, P.R. China.
2
State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, P.R. China.
3
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325000, P.R. China.
4
The Engineering Research Center of Peptide Drug Discovery and Development, China Pharmaceutical University, Nanjing, 211100, P.R. China.
5
School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211100, P.R. China. lao@cpu.edu.cn.
6
School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211100, P.R. China. zhengh18@hotmail.com.

Abstract

Data Repository of Antimicrobial Peptides (DRAMP, http://dramp.cpu-bioinfor.org/ ) is an open-access comprehensive database containing general, patent and clinical antimicrobial peptides (AMPs). Currently DRAMP has been updated to version 2.0, it contains a total of 19,899 entries (newly added 2,550 entries), including 5,084 general entries, 14,739 patent entries, and 76 clinical entries. The update covers new entries, structures, annotations, classifications and downloads. Compared with APD and CAMP, DRAMP contains 14,040 (70.56% in DRAMP) non-overlapping sequences. In order to facilitate users to trace original references, PubMed_ID of references have been contained in activity information. The data of DRAMP can be downloaded by dataset and activity, and the website source code is also available on dedicatedly designed download webpage. Although thousands of AMPs have been reported, only a few parts have entered clinical stage. In the paper, we described several AMPs in clinical trials, including their properties, indications and clinicaltrials.gov identifiers. Finally, we provide the applications of DRAMP in the development of AMPs.

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