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BMC Infect Dis. 2019 Aug 13;19(1):713. doi: 10.1186/s12879-019-4348-x.

Clinical benefits of FilmArray meningitis-encephalitis PCR assay in partially-treated bacterial meningitis in Israel.

Author information

1
Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. yairmi@tlvmc.gov.il.
2
Neurological Institute, Tel-Aviv Sourasky Medical Center, 6th Weizman street, Tel-Aviv, Israel. yairmi@tlvmc.gov.il.
3
Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
4
Division of Epidemiology and Preventive Medicine, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
5
Tel-Aviv District, Israel Ministry of Health, Tel-Aviv, Israel.
6
Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.
7
Department of Pediatrics C, Schneider Children's Medical Center, Petah Tikva, Israel.
8
Microbiology Laboratory, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.
9
Microbiology Laboratory, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

Abstract

BACKGROUND:

Management of partially-treated, community-acquired bacterial meningitis (PCBM) is commonly compromised by lack of microbiological diagnosis. We aimed to analyze the impact of FilmArray Meningitis-Encephalitis (FA-ME) PCR on the management of PCBM.

METHODS:

Comparison of treatment variables of PCBM cases between two periods, before (6.5 years, control group) and after (2 years, study group) the application of FA-ME PCR assay.

RESULTS:

The total duration of antimicrobial treatment in the study group (n = 8) was significantly shorter than the control group (n = 23) (9.5 ± 3.7 days vs. 15.2 ± 5 days, p = 0.007). The percentage of narrow-spectrum regimens was significantly higher in the study group (78 ± 11% vs. 40 ± 9%, p = 0.03). There was a significant difference in implementation of antimicrobial chemoprophylaxis for close contacts (4/8 (50%) vs. 1/23 (4%), p = 0.01).

CONCLUSIONS:

The use of FA-ME PCR provides significant benefits in the management of PCBM by shortening duration of antibiotic treatment, increasing the use of narrow-spectrum regimens, and allowing proper administration of antimicrobial chemoprophylaxis.

TRIAL REGISTRATION:

The study was approved and retrospectively registered by the Tel-Aviv Sourasky Medical Center ( 0378-17-TLV , 10/17/2017) and Rabin Medical Center ( 0270-18-RMC , 11/11/2018) Ethics committees and conforms to recognized standards.

KEYWORDS:

Bacteriology; Meningitis; Polymerase chain reaction

PMID:
31409318
PMCID:
PMC6693273
DOI:
10.1186/s12879-019-4348-x
[Indexed for MEDLINE]
Free PMC Article

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