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Antioxidants (Basel). 2019 Aug 12;8(8). pii: E302. doi: 10.3390/antiox8080302.

Health Benefits of Nut Consumption in Middle-Aged and Elderly Population.

Author information

1
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, "Luliu Hatieganu" University of Medicine and Pharmacy, 8 Victor Babes, 400012 Cluj-Napoca, Romania.
2
Department of Pharmaceutical Botany, Faculty of Pharmacy, "Luliu Hatieganu" University of Medicine and Pharmacy, 8 Victor Babes, 400012 Cluj-Napoca, Romania.
3
Laboratory of Chromatography, ICHAT, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania.
4
Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança (IPB), Campus de Santa Apolónia, 5300-253 Bragança, Portugal. iferreira@ipb.pt.
5
Department of Toxicology, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, 8 Victor Babes, 400012 Cluj-Napoca, Romania.

Abstract

Aging is considered the major risk factor for most chronic disorders. Oxidative stress and chronic inflammation are two major contributors for cellular senescence, downregulation of stress response pathways with a decrease of protective cellular activity and accumulation of cellular damage, leading in time to age-related diseases. This review investigated the most recent clinical trials and cohort studies published in the last ten years, which presented the influence of tree nut and peanut antioxidant diets in preventing or delaying age-related diseases in middle-aged and elderly subjects (≥55 years old). Tree nut and peanut ingestion has the possibility to influence blood lipid count, biochemical and anthropometric parameters, endothelial function and inflammatory biomarkers, thereby positively affecting cardiometabolic morbidity and mortality, cancers, and cognitive disorders, mainly through the nuts' healthy lipid profile and antioxidant and anti-inflammatory mechanisms of actions. Clinical evidence and scientific findings demonstrate the importance of diets characterized by a high intake of nuts and emphasize their potential in preventing age-related diseases, validating the addition of tree nuts and peanuts in the diet of older adults. Therefore, increased consumption of bioactive antioxidant compounds from nuts clearly impacts many risk factors related to aging and can extend health span and lifespan.

KEYWORDS:

age-related diseases; antioxidants; elderly; inflammation; middle-aged population; nut-enriched Mediterranean diet; oxidative stress; peanuts; tree nuts

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