Format

Send to

Choose Destination
World J Surg. 2019 Aug 12. doi: 10.1007/s00268-019-05125-5. [Epub ahead of print]

Outcomes After Urgent Thyroidectomy Following Rapid Control of Thyrotoxicosis in Graves' Disease are Similar to Those After Elective Surgery in Well-Controlled Disease.

Author information

1
Endocrine Surgery Unit, Sheffield Teaching Hospitals NHS Foundation Trust, F8, Ward F2, Royal Hallamshire Hospital, Beech Hill Road, Sheffield, S10 2JF, UK.
2
Department of Endocrinology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
3
Endocrine Surgery Unit, Sheffield Teaching Hospitals NHS Foundation Trust, F8, Ward F2, Royal Hallamshire Hospital, Beech Hill Road, Sheffield, S10 2JF, UK. s.p.balasubramanian@sheffield.ac.uk.
4
Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK. s.p.balasubramanian@sheffield.ac.uk.

Abstract

BACKGROUND:

Surgery for Graves' disease (GD) is usually performed after adequate control with medical treatment. Occasionally, rapid pre-operative optimization is required. The primary objective was to compare the outcomes of patients undergoing elective surgery for well-controlled GD with those undergoing rapid pre-operative treatment. We also propose a formal treatment protocol for future use.

METHODS:

A retrospective cohort study in a tertiary referral centre included 247 patients with well-controlled GD undergoing elective surgery and 19 patients with poorly controlled disease undergoing surgery after rapid optimization. The latter group did not respond well to thionamides (carbimazole and/or propylthiouracil) or had intolerance or side effects to thionamides and were treated with a range of non-thionamide drugs, including Lugol's iodine, cholestyramine, beta blockers and steroids (with or without thionamides), and closely monitored for 1-2 weeks before surgery. Outcome measures included thyroid storm, hypoparathyroidism and recurrent laryngeal nerve palsy.

RESULTS:

In total, 266 patients with male-to-female ratio of 1:6 and median (interquartile range) age of 39 (31-51) were included. Overall, long-term recurrent laryngeal palsy and hypoparathyroidism occurred in 1 (0.38%) and 13 (4.9%) patients, respectively. No patient had thyroid storm. There was no significant difference in hypoparathyroidism (p = 1), vocal cord palsy (p = 0.803) and post-operative bleeding (p = 0.362), between elective surgery and rapid optimization groups.

CONCLUSION:

Rapid pre-operative treatment is effective, safe and is associated with similar outcomes compared to usual treatment. A rapid pre-operative optimization protocol is proposed.

PMID:
31407090
DOI:
10.1007/s00268-019-05125-5

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center