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Respirol Case Rep. 2019 Aug 7;7(7):e00473. doi: 10.1002/rcr2.473. eCollection 2019 Oct.

Invasive tracheal aspergillosis after chemoradiotherapy treatment.

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Department of Thoracic Medicine Royal Adelaide Hospital Adelaide South Australia Australia.
Adelaide Medical School, Faculty of Health and Medical Sciences The University of Adelaide Adelaide South Australia Australia.


Invasive tracheobronchial aspergillosis is a rare disease with most reported cases in the literature occurring in immunocompromised hosts. We report an unusual case of a patient with persistent cough and dyspnoea in the context of prior chemoradiotherapy for primary lung cancer. Chest computed tomography (CT) demonstrated an abnormal soft tissue mass surrounding the trachea and carina, with focal moderate fluorodeoxyglucose (FDG) activity on positron emission tomography (PET) scan. Bronchoscopic biopsy revealed fungal hyphae associated with necrosis and cartilage invasion, subsequently confirmed to be Aspergillus fumigatus complex. The patient was commenced on antifungal therapy promptly and had a good clinical response to treatment.


Bronchoscopy and interventional techniques; infection and inflammation; pathology; respiratory infections (non‐tuberculous)

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