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J Biol Eng. 2019 Aug 7;13:68. doi: 10.1186/s13036-019-0197-9. eCollection 2019.

The LINC complex, mechanotransduction, and mesenchymal stem cell function and fate.

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1Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, W317.3 Nebraska Hall, Lincoln, NE 68588 USA.
2Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE USA.
3Division of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE USA.


Mesenchymal stem cells (MSCs) show tremendous promise as a cell source for tissue engineering and regenerative medicine, and are understood to be mechanosensitive to external mechanical environments. In recent years, increasing evidence points to nuclear envelope proteins as a key player in sensing and relaying mechanical signals in MSCs to modulate cellular form, function, and differentiation. Of particular interest is the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex that includes nesprin and SUN. In this review, the way in which cells can sense external mechanical environments through an intact nuclear envelope and LINC complex proteins will be briefly described. Then, we will highlight the current body of literature on the role of the LINC complex in regulating MSC function and fate decision, without and with external mechanical loading conditions. Our review and suggested future perspective may provide a new insight into the understanding of MSC mechanobiology and related functional tissue engineering applications.


Functional tissue engineering; Linker of Nucleoskeleton and cytoskeleton (LINC); Mechanotransduction; Mesenchymal stem cells; Nesprin; SUN

Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

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