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Nucleus. 2019 Dec;10(1):213-217. doi: 10.1080/19491034.2019.1649835.

The cell nucleus. A study in Burgundy.

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a INSERM UMR1231, Laboratory of Excellence LipSTIC, University of Burgundy Franche-Comté , Dijon , France.
b Insitutute of Cytology, Russian Academy of Sciences and Petrov Institute of Oncology , Saint-Petersburg , Russia.
c Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH , Bethesda , MD , USA.


Wilhelm Bernhard's revolutionary microscopy techniques helped him put forward the hypothesis of specialized compartmentalization of the nucleus. He also described for the first time the nuclear bodies and peri-chromatin fibrils, and demonstrated that these granules contain an RNA component. The tradition of biennial workshops, named after this great scientist, continues, and this year it took place in the heart of Burgundy, in Dijon, France (May 20-24, 2019, organized by INSERM UMR1231, UBFC), where well-fed participants emphasized the importance of viewing the cell nucleus as a hub of specialized colloidal compartments that orchestrate replication, transcription and nuclear transport.


Phase separation; lamins; nuclear pores; nucleolus

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