Ecological interventions to prevent and manage zoonotic pathogen spillover

Susanne H Sokolow; Nicole Nova; Kim M Pepin; Alison J Peel; Juliet R C Pulliam; Kezia Manlove; Paul C Cross; Daniel J Becker; Raina K Plowright; Hamish McCallum; Giulio A De Leo

doi:10.1098/rstb.2018.0342

Ecological interventions to prevent and manage zoonotic pathogen spillover

Philos Trans R Soc Lond B Biol Sci. 2019 Sep 30;374(1782):20180342. doi: 10.1098/rstb.2018.0342. Epub 2019 Aug 12.

Authors

Susanne H Sokolow^{1

2

3}, Nicole Nova⁴, Kim M Pepin⁵, Alison J Peel⁶, Juliet R C Pulliam⁷, Kezia Manlove⁸, Paul C Cross⁹, Daniel J Becker^{10

11}, Raina K Plowright¹⁰, Hamish McCallum⁶, Giulio A De Leo^{1

2

4}

Affiliations

¹ Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA.
² Woods Institute for the Environment, Stanford University, Stanford, CA 94305, USA.
³ Marine Science Institute, University of California, Santa Barbara, CA 93106, USA.
⁴ Department of Biology, Stanford University, Stanford, CA 94305, USA.
⁵ National Wildlife Research Center, USDA-APHIS, Fort Collins, CO 80521, USA.
⁶ Environmental Futures Research Institute, Griffith University, Nathan, Queensland 4111, Australia.
⁷ South African DST-NRF Centre of Excellence in Epidemiological Modelling and Analysis (SACEMA), Stellenbosch University, Stellenbosch 7600, South Africa.
⁸ Department of Wildland Resources and Ecology Center, Utah State University, Logan, UT 84321, USA.
⁹ US Geological Survey, Northern Rocky Mountain Science Center, Bozeman, MT 59715, USA.
¹⁰ Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA.
¹¹ Department of Biology, Indiana University, Bloomington, IN 47403, USA.

Abstract

Spillover of a pathogen from a wildlife reservoir into a human or livestock host requires the pathogen to overcome a hierarchical series of barriers. Interventions aimed at one or more of these barriers may be able to prevent the occurrence of spillover. Here, we demonstrate how interventions that target the ecological context in which spillover occurs (i.e. ecological interventions) can complement conventional approaches like vaccination, treatment, disinfection and chemical control. Accelerating spillover owing to environmental change requires effective, affordable, durable and scalable solutions that fully harness the complex processes involved in cross-species pathogen spillover. This article is part of the theme issue 'Dynamic and integrative approaches to understanding pathogen spillover'.

Keywords: cross-species transmission; ecological interventions; management; spillover; zoonotic diseases.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Animals, Wild
Communicable Diseases, Emerging / prevention & control*
Communicable Diseases, Emerging / veterinary*
Humans
Models, Biological
Zoonoses / prevention & control*

Associated data

figshare/10.6084/m9.figshare.c.4560638

Abstract

Publication types

MeSH terms

Associated data

Grants and funding