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Mult Scler Relat Disord. 2019 Oct;35:209-214. doi: 10.1016/j.msard.2019.08.004. Epub 2019 Aug 5.

Changing patterns of multiple sclerosis in Korea: Toward a more baseline MRI lesions and intrathecal humoral immune responses.

Author information

1
Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Republic of Korea; Department of Neurology, Chonbuk National University School of Medicine, Jeonju, Republic of Korea.
2
Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Republic of Korea.
3
Department of Neurology, Yeungnam University College of Medicine, Daegu, Republic of Korea.
4
Department of Neurology, Chungnam National University School of Medicine, Deajeon, Republic of Korea.
5
Department of Neurology, Korea University Medical Center, Korea University College of Medicine, Seoul, Republic of Korea.
6
Department of Neurology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
7
Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.
8
Department of Neurology, Nowon Eulji Medical Center, Eulji University College of Medicine, Seoul, Republic of Korea.
9
Department of Neurology, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Republic of Korea.
10
Department of Neurology, Seoul Medical Center, Seoul, Republic of Korea.
11
Department of Neurology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.
12
Department of Neurology, Chonbuk National University School of Medicine, Jeonju, Republic of Korea.
13
Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
14
Department of Neurology, Gyeongsang National University Hospital, Jinju, Republic of Korea.
15
Department of Neurology, Jeju National University School of Medicine, Jeju, Republic of Korea.
16
Department of Neurology, Eulji University Hospital, Daejeon, Republic of Korea.
17
Medical Research Collaborating Center, Seoul National University Hospital, Seoul, Republic of Korea.
18
Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea.
19
Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Republic of Korea. Electronic address: hojinkim@ncc.re.kr.
20
Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: sueh916@gmail.com.

Abstract

BACKGROUND:

The environmental risks of multiple sclerosis (MS), including adolescent obesity and vitamin D deficiency, are increasing in Korea. We aimed to determine whether the patterns and/or severity of MS in Korea can change according to the year of birth or disease onset.

METHODS:

Two hundred and sixty-six patients with adult-onset MS, including 164 with an available baseline magnetic resonance imaging (MRI), were retrospectively included from 17 nationwide referral hospitals in Korea. The demographics, MRI T2 lesion burden at disease onset, cerebrospinal fluid markers, and prognosis were assessed.

RESULTS:

The birth year, time from disease onset to first MRI, and female sex were associated with a higher number of baseline MRI T2 lesions. The birth year was also associated with the presence of oligoclonal band in the cerebrospinal fluid and high immunoglobin G index. An increased female/male ratio was observed among those with a more recent year of birth and/or disease onset.

CONCLUSIONS:

In Korea, the disease pattern of adult-onset MS may be changing toward a more baseline T2 MRI lesions, intrathecal humoral immune responses, and also higher female ratio.

KEYWORDS:

Asian; Epidemiology; MRI; Multiple sclerosis; Oligoclonal band

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