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Trends Cell Biol. 2019 Oct;29(10):770-776. doi: 10.1016/j.tcb.2019.07.007. Epub 2019 Aug 7.

Extracellular Vesicles: Catching the Light in Zebrafish.

Author information

1
Institute for Psychiatry and Neuroscience Paris, Hôpital Saint-Anne, Université Descartes, Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1266, 75015 Paris, France.
2
INSERM Unité Mixte de Recherche en Santé (UMRS) 1109, 67200 Strasbourg, France; Université de Strasbourg, 67000 Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg (FMTS), 67000 Strasbourg, France; Centre National de la Recherche Scientifique (CNRS) SNC5055, Strasbourg, France.
3
Institute for Psychiatry and Neuroscience Paris, Hôpital Saint-Anne, Université Descartes, Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1266, 75015 Paris, France. Electronic address: guillaume.van-niel@inserm.fr.
4
INSERM Unité Mixte de Recherche en Santé (UMRS) 1109, 67200 Strasbourg, France; Université de Strasbourg, 67000 Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg (FMTS), 67000 Strasbourg, France. Electronic address: jacky.goetz@inserm.fr.

Abstract

Extracellular vesicles (EVs) circulate in the body fluids of all organisms where they participate in intercellular cross-organ communication. Tracking and understanding these nanosized objects has been hampered by the low resolution of imaging techniques and by the lack of appropriate animal models. The use of zebrafish embryos permits visualization of EVs at unprecedented spatiotemporal resolution using light and electron microscopy. This enables the study of endogenous physiological EVs and pathological EVs side by side, and further unravels their mechanisms of biogenesis, biodistribution, and target cells throughout the organism. These developments will contribute to a better understanding of the in vivo (patho)physiology of EVs.

KEYWORDS:

circulation; exosomes; extracellular vesicles; high-resolution imaging; in vivo; zebrafish

PMID:
31400828
DOI:
10.1016/j.tcb.2019.07.007

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