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Trends Pharmacol Sci. 2019 Aug 7. pii: S0165-6147(19)30144-0. doi: 10.1016/j.tips.2019.07.007. [Epub ahead of print]

Cell-Specific Neuropharmacology.

Author information

1
Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), CNRS, INSERM, Sorbonne Université, Paris, France.
2
Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), CNRS, INSERM, Sorbonne Université, Paris, France; Nash Family Department of Neuroscience, Center for Affective Neuroscience, and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
3
Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), CNRS, INSERM, Sorbonne Université, Paris, France. Electronic address: alexandre.mourot@upmc.fr.

Abstract

Neuronal communication involves a multitude of neurotransmitters and an outstanding diversity of receptors and ion channels. Linking the activity of cell surface receptors and ion channels in defined neural circuits to brain states and behaviors has been a key challenge in neuroscience, since cell targeting is not possible with traditional neuropharmacology. We review here recent technologies that enable the effect of drugs to be restricted to specific cell types, thereby allowing acute manipulation of the brain's own proteins with circuit specificity. We highlight the importance of developing cell-specific neuropharmacology strategies for decoding the nervous system with molecular and circuit precision, and for developing future therapeutics with reduced side effects.

KEYWORDS:

bump-hole; chemogenetics; optogenetics; photopharmacology; receptor–ligand pair; tethered ligand

PMID:
31400823
DOI:
10.1016/j.tips.2019.07.007

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