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Enferm Infecc Microbiol Clin. 2019 Aug 7. pii: S0213-005X(19)30205-8. doi: 10.1016/j.eimc.2019.06.009. [Epub ahead of print]

Evolution of the antimicrobial resistance rates in clinical isolates of Pseudomonas aeruginosa causing invasive infections in the south of Spain.

[Article in English, Spanish]

Author information

1
Unidad de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena, Sevilla, España; Departamento de Microbiología, Universidad de Sevilla, España; Instituto de Biomedicina de Sevilla IBIS, Hospital Universitario Virgen Macarena/CSIC/Universidad de Sevilla, Sevilla, España; Red Española de Investigación en Patología Infecciosa (REIPI RD16/0016), Instituto de Salud Carlos III, Madrid, España. Electronic address: felipefc@us.es.
2
Red Española de Investigación en Patología Infecciosa (REIPI RD16/0016), Instituto de Salud Carlos III, Madrid, España; Unidad de Gestión Clínica de Microbiología, Hospital Universitario Reina Sofía, Córdoba, España; Departamento de Microbiología, Universidad de Córdoba, España; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Hospital Universitario Reina Sofía/Universidad de Córdoba, Córdoba, España.
3
Unidad de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena, Sevilla, España; Departamento de Microbiología, Universidad de Sevilla, España; Instituto de Biomedicina de Sevilla IBIS, Hospital Universitario Virgen Macarena/CSIC/Universidad de Sevilla, Sevilla, España; Red Española de Investigación en Patología Infecciosa (REIPI RD16/0016), Instituto de Salud Carlos III, Madrid, España.
4
H. Infanta Cristina, Badajoz.
5
H. San Pedro de Alcántara, Cáceres.
6
H. Virgen del Puerto, Plasencia, Cáceres.
7
H. General de Mérida, Mérida, Badajoz.
8
H. Don Benito, Badajoz.
9
H. Virgen de las Nieves, Granada.
10
H. Universitario San Cecilio, Granada.
11
H. Torrecárdenas, Almería.
12
Complejo Hospitalario Jaén, Jaén.
13
H. Virgen de la Victoria, Málaga.
14
H. Regional de Málaga, Málaga.
15
H. Virgen del Rocío, Sevilla.
16
H. La Merced, Osuna, Sevilla.
17
H. Reina Sofía, Córdoba.
18
H. Juan Ramón Jiménez (Huelva).
19
H. Puerta del Mar, Cádiz.
20
H. de Jerez, Cádiz.
21
H. de Ceuta, Ceuta.
22
H. Puerto Real, Cádiz.

Abstract

INTRODUCTION:

The aim of this study was to determine the antimicrobial resistance rates and their evolution in clinical isolates of Pseudomonas aeruginosa causing invasive infections in the south of Spain between 2012 and 2017.

METHODS:

Retrospective study consisting of the collection of microbiological data from 20 hospitals (14 from Andalucía, 5 from Extremadura and 1 from Ceuta) between 2012 and 2017. The main variables studied were the antimicrobial susceptibility testing system used, interpretation criteria (CLSI or EUCAST) and the rate or percentage of resistant isolates.

RESULTS:

The most widely used antimicrobial susceptibility testing system was MicroScan (58%). The global resistance rates varied between 25% (ciprofloxacin) and 4% (colistin) using EUCAST, and between 19% (ciprofloxacin and imipenem) and 3% (amikacin) using CLSI. The antimicrobial resistance rates were relatively stable throughout the period 2012-2017. 14% of isolates were MDR and 7% were XDR. Respiratory isolates were more resistant, particularly to ciprofloxacin and colistin, than isolates from urine or blood.

CONCLUSIONS:

The antimicrobial resistance rates in P. aeruginosa are not particularly high in the south of Spain. The highest resistance rates were observed with ciprofloxacin, piperacillin/tazobactam and meropenem, whereas the more active antimicrobials were colistin, tobramycin and amikacin. The highest resistance rates were seen in respiratory isolates. In general, the resistance rates remained stable during the study period for most of the antimicrobials studied.

KEYWORDS:

Aislados invasivos; Antimicrobial resistance; España; Invasive isolates; Pseudomonas aeruginosa; Resistencia antimicrobiana; Spain

PMID:
31399254
DOI:
10.1016/j.eimc.2019.06.009

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