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Cell Mol Gastroenterol Hepatol. 2019 Aug 6. pii: S2352-345X(19)30096-7. doi: 10.1016/j.jcmgh.2019.07.008. [Epub ahead of print]

Peripheral blood T cell fitness is diminished in patients with pancreatic carcinoma but can be improved with homeostatic cytokines.

Author information

1
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA.
2
Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
3
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
4
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
5
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
6
Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA. Electronic address: mej@pennmedicine.upenn.edu.
7
Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. Electronic address: gregory.beatty@pennmedicine.upenn.edu.

KEYWORDS:

PDAC; T cell; cytokines; immune dysfunction; immunotherapy

PMID:
31398492
DOI:
10.1016/j.jcmgh.2019.07.008
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