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Gynecol Obstet Fertil Senol. 2019 Aug 6. pii: S2468-7189(19)30241-7. doi: 10.1016/j.gofs.2019.07.018. [Epub ahead of print]

[Prenatal diagnosis and postnatal outcome of isolated intra-abdominal calcifications: a 10-year experience from a referral fetal medicine center].

[Article in French]

Author information

1
Service de Médecine Fœtale, Hôpital Trousseau, Paris, France. Electronic address: emelinem@yahoo.com.
2
Service de Gynécologie-Obstétrique, Hôpital Trousseau, Paris, France.
3
Service de Radiologie Pédiatrique, Hôpital Trousseau, Paris, France.
4
Service de Chirurgie Pédiatrique, Hôpital Trousseau, Paris, France.
5
Service de Médecine Fœtale, Hôpital Trousseau, Paris, France.
6
Service de Médecine Fœtale, Hôpital Trousseau, Paris, France; Médecine Sorbonne Université, Paris, France.
7
Service de Gynécologie-Obstétrique, Hôpital Trousseau, Paris, France; Médecine Sorbonne Université, Paris, France.

Abstract

INTRODUCTION:

Intra-abdominal calcifications (iAC) detected during fetal ultrasound examinations are characterized by their isolated or associated nature, as well as their location. Our objective was to describe all cases of isolated iAC along with their etiological investigations and neonatal outcome, during a 10-year practice in a referral center.

METHODS:

We conducted a retrospective descriptive monocentric study on neonates diagnosed with isolated iAC after antenatal expert ultrasound scan and referred to the Multidisciplinary Center for Prenatal Diagnosis at Trousseau Hospital and born between January 1st, 2008 and June 30th, 2018. The exclusion criteria were: retroperitoneal calcifications, iAC associated with other digestive abnormalities or with congenital malformations.

RESULTS:

The 32 isolated iAC cases accounted for 46% of all iAC. Nine cases were excluded for missing neonatal data. Among the 23 remaining isolated iAC cases, we observed 15 intra-hepatic calcifications, 5 peri-hepatic and two peritoneal calcifications. One fetus had both intra- and peri-hepatic calcifications. The majority of iAC remained stable throughout pregnancy. No cases of aneuploidy, fetal infection, or cystic fibrosis were detected. The neonatal outcome was favorable in all cases.

CONCLUSIONS:

In case of isolated and stable iAC after expert ultrasound scan, after having ruled out infectious diseases of the fetus and looked for the most frequent mutations of cystic fibrosis in the parents, the prognosis is favorable. Fetal karyotyping is recommended when additional structural anomalies are present.

KEYWORDS:

Calcification intra-abdominale; Intra-abdominal calcification; calcification peritonéale; fetal hepatic hyperchogenicities; hyperéchogénicité hépatique fœtale; hyperéchogénicité péritonéale; intra-peritoneal calcification; intraperitoneal echogenic foci

PMID:
31398445
DOI:
10.1016/j.gofs.2019.07.018

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