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Clin Exp Immunol. 2019 Aug 9. doi: 10.1111/cei.13360. [Epub ahead of print]

Birth and coming of age of islet autoantibodies.

Author information

1
Technische Universität Dresden, DFG Center for Regenerative Therapies Dresden, Dresden, Germany.
2
Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital Carl Gustav Carus and Faculty of Medicine, TU, Dresden, Germany.
3
Institute of Diabetes Research, Helmholtz Zentrum M√ľnchen, German Research Center for Environmental Health, Munich-Neuherberg, Germany.
4
Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Forschergruppe Diabetes, Munich, Germany.

Abstract

This review takes the reader through 45 years of islet autoantibody research, from the discovery of islet-cell antibodies in 1974 to today's population-based screening for presymptomatic early-stage type 1 diabetes. The review emphasizes the current practical value of, and factors to be considered in, the measurement of islet autoantibodies. This article is protected by copyright. All rights reserved.

KEYWORDS:

ICA ; autoantibodies; islet-cell antibodies; type 1 diabetes

PMID:
31397889
DOI:
10.1111/cei.13360

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