Send to

Choose Destination
J Infect Dis. 1988 Oct;158(4):766-72.

Prevention of intra-abdominal abscesses by fibrinolysis using recombinant tissue plasminogen activator.

Author information

Department of Surgery, University of Toronto, Toronto General Hospital, Ontario, Canada.


We studied whether intraperitoneal fibrinolysis using recombinant tissue plasminogen activator (t-PA) could prevent abscess formation in the rat model of intra-abdominal infection caused by fibrin clots. Single-dose administration of t-PA at concentrations greater than 0.005 mg/mL at surgery or delivered by open lavage within 1 h of surgery completely obviated abscess formation induced by Bacteroides fragilis-infected clots without altering mortality (approximately 0.6%). With mixed Escherichia coli-B. fragilis clots, t-PA increased the mortality rate from the control level of 43.8% to 81.3% but prevented abscesses in survivors. This increased mortality rate was probably due to an acute E. coli bacteremia. Antibiotics plus t-PA prevented both mortality and abscess formation. Intraperitoneal fibrinolysis may be a useful adjunct to antibiotics and appropriate surgery in the management of intra-abdominal infection.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center