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Indian J Dermatol Venereol Leprol. 2019 Aug 9. doi: 10.4103/ijdvl.IJDVL_777_18. [Epub ahead of print]

A retrospective study: Clinicopathological and immunohistochemical analysis of 54 cases of tufted angioma.

Author information

1
Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shanxi Province, China.

Abstract

Background:

Tufted angioma is a rare benign lesion with vascular proliferation.

Aim:

To retrospectively analyze the clinicopathological manifestations and immunohistochemical features of tufted angioma.

Methods:

Clinical and histopathological features of tufted angioma (n = 54) were evaluated and analyzed retrospectively in the Department of Dermatology, Xijing Hospital from 2003 to 2014.

Results:

Clinically, tufted angioma usually presented as erythematous plaques and papules on the head and neck (n = 11), trunk (n = 21) and extremities (n = 22), mainly in children (n = 48), without gender difference (24 males and 30 females). A total of 45 cases showed solitary lesions and nine cases showed multiple lesions. Common symptoms included pain (n = 11), tenderness (n = 7), itching (n = 1), hypertrichosis (n = 7), hyperhidrosis (n = 6) and Kasabach-Merritt phenomenon (n = 1). Histopathologically, typical tufted angioma (n = 37) showed proliferation of endothelial cells in a so-called cannonball pattern, while in the early (n = 4) and regressed (n = 13) stages the tufted appearance was not prominent. The proliferated endothelial cells were diffusely positive for CD31 and Wilms tumor 1, focally positive for D2-40 and Prox1, and negative for Glut-1.

Limitations:

Our research was confined to patients of Chinese origin and our sample size was limited.

Conclusions:

Tufted angioma is a rare vascular neoplasm with diverse clinical manifestations and unique pathological features. It should be recognized as a vascular tumor with lymphatic differentiation. We emphasize the importance of considering tufted angioma in the differential diagnoses of any congenital or acquired vascular tumor.

KEYWORDS:

Hemangioma; pathology; tufted angioma

PMID:
31397400
DOI:
10.4103/ijdvl.IJDVL_777_18
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