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Micromachines (Basel). 2019 Aug 9;10(8). pii: E525. doi: 10.3390/mi10080525.

A Wireless Implantable System for Facilitating Gastrointestinal Motility.

Author information

1
Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
2
Division of Pediatric Surgery, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
3
Division of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
4
Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
5
Niche Biomedical Inc., Los Angeles, CA 90095, USA.
6
Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA. wentai@ucla.edu.

Abstract

Gastrointestinal (GI) electrical stimulation has been shown in several studies to be a potential treatment option for GI motility disorders. Despite the promising preliminary research progress, however, its clinical applicability and usability are still unknown and limited due to the lack of a miniaturized versatile implantable stimulator supporting the investigation of effective stimulation patterns for facilitating GI dysmotility. In this paper, we present a wireless implantable GI modulation system to fill this technology gap. The system consists of a wireless extraluminal gastrointestinal modulation device (EGMD) performing GI electrical stimulation, and a rendezvous device (RD) and a custom-made graphical user interface (GUI) outside the body to wirelessly power and configure the EGMD to provide the desired stimuli for modulating GI smooth muscle activities. The system prototype was validated in bench-top and in vivo tests. The GI modulation system demonstrated its potential for facilitating intestinal transit in the preliminary in vivo chronic study using porcine models.

KEYWORDS:

bioelectronics medicine; electroceuticals; gastrointestinal stimulation; implant; motility; neuromodulation

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