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AJNR Am J Neuroradiol. 2019 Aug 8. doi: 10.3174/ajnr.A6145. [Epub ahead of print]

Optimal Detection of Subtle Gadolinium Leakage in CSF with Heavily T2-Weighted Fluid-Attenuated Inversion Recovery Imaging.

Author information

1
From the Department of Psychiatry and Neuropsychology (W.M.F., R.W.v.H., H.I.L.J., F.R.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht, the Netherlands.
2
Department of Radiology and Nuclear Medicine (W.M.F., W.M.P., J.F.A,J., W.H.B.), Maastricht University Medical Center, School for Mental Health and Neuroscience, Maastricht, the Netherlands.
3
Departments of Radiology (D.N.t.W.).
4
Neurology (E.I.H.), Zuyderland Medical Center Heerlen, Heerlen, the Netherlands.
5
Department of Radiology and Nuclear Medicine (W.M.F., W.M.P., J.F.A,J., W.H.B.), Maastricht University Medical Center, School for Mental Health and Neuroscience, Maastricht, the Netherlands. w.backes@mumc.nl.

Abstract

Pericortical enhancement on postcontrast FLAIR images is a marker for subtle leptomeningeal blood-brain barrier leakage. We explored the optimal FLAIR sequence parameters for the detection of low gadolinium concentrations within the CSF. On the basis of phantom experiments and human in vivo data, we showed that detection of subtle pericortical enhancement can be facilitated by using a relatively long TE. Future studies should choose their FLAIR sequence parameters carefully when assessing pericortical enhancement due to subtle blood-brain barrier leakage.

PMID:
31395665
DOI:
10.3174/ajnr.A6145

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