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Nutrients. 2019 Aug 7;11(8). pii: E1823. doi: 10.3390/nu11081823.

Choline: Exploring the Growing Science on Its Benefits for Moms and Babies.

Author information

1
Program in Biochemistry, Graduate Center of the City University of New York, New York, NY 10016, USA.
2
Department of Health and Nutrition Sciences, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA.
3
Program in Biochemistry, Graduate Center of the City University of New York, New York, NY 10016, USA. xinyinjiang@brooklyn.cuny.edu.
4
Department of Health and Nutrition Sciences, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA. xinyinjiang@brooklyn.cuny.edu.
5
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA. mac379@cornell.edu.

Abstract

The importance of ensuring adequate choline intakes during pregnancy is increasingly recognized. Choline is critical for a number of physiological processes during the prenatal period with roles in membrane biosynthesis and tissue expansion, neurotransmission and brain development, and methyl group donation and gene expression. Studies in animals and humans have shown that supplementing the maternal diet with additional choline improves several pregnancy outcomes and protects against certain neural and metabolic insults. Most pregnant women in the U.S. are not achieving choline intake recommendations of 450 mg/day and would likely benefit from boosting their choline intakes through dietary and/or supplemental approaches.

KEYWORDS:

choline; cognitive development; epigenetic programming; placenta; pregnancy outcomes

PMID:
31394787
PMCID:
PMC6722688
DOI:
10.3390/nu11081823
[Indexed for MEDLINE]
Free PMC Article

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