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Biosci Biotechnol Biochem. 2019 Aug 8:1-9. doi: 10.1080/09168451.2019.1651627. [Epub ahead of print]

Electronic cigarette exposure reduces exercise performance and changes the biochemical profile of female mice.

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a Health Technology College, Jilin Sport University , Changchun , Jilin , China.
b Graduate Institute of Sports Science, National Taiwan Sport University , Taoyuan , Taiwan.
c Department of Anatomy, College of Medicine, Chang Gung University , Taoyuan , Taiwan.
d Aesthetic Medical Center, Department of Dermatology, Chang Gung Memorial Hospital , Taoyuan , Taiwan.
e Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology , Taoyuan , Taiwan.
f Research Center for Industry of Human Ecology and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology , Taoyuan , Taiwan.


Electronic cigarette(s) (EC) becoming a preferred replacement for nicotine delivery among many smokers in recent years. However, the effect of EC on human health is inconclusive due to a lack of empirical research investigating EC-induced health hazard or benefit. In this study, we examine the effect of vapor produced by EC on exercise performance and health-related profiles in a mouse model. Female ICR mice were divided into five groups (n = 6 per group) and exposed for 14 days. Our results indicate that EC exposure leads to dose-dependent decrease in the grip strength and swimming time of the mice. The EC-treated groups also showed a dose-dependent decrease in liver and muscle glycogen storage. In addition, EC treatment had no negative effect on levels of biochemical indices. We also did not detect any adverse effect or gross abnormalities on the morphology of the major organs.


Electronic cigarettes; exercise performance; glycogen; nicotine delivery systems

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