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Animal Model Exp Med. 2019 Apr 30;2(2):107-113. doi: 10.1002/ame2.12067. eCollection 2019 Jun.

Effect of the hyaluronic acid-poloxamer hydrogel on skin-wound healing: in vitro and in vivo studies.

Author information

1
Research Center for Clinical and Translational Medicine Fifth Medical Center General Hospital of Chinese PLA Beijing People's Republic of China.
2
Department of Rheumatology and Immunology Fifth Hospital of Qingdao City Qingdao Shandong Province People's Republic of China.
3
Center for Clinical Laboratory Fifth Medical Center General Hospital of Chinese PLA Beijing People's Republic of China.

Abstract

Background:

Recent research into skin injury and wound healing has focused mainly on post-trauma hemostasis, infection prevention, dermal regeneration and angiogenesis. However, less attention has been paid to air permeability and moisture loss prevention which also play important roles in injury healing.

Methods:

In the present work, we prepared a hyaluronic acid-poloxamer (HA-POL) hydrogel and tested the therapeutic effect of the hydrogel on skin-wound healing.

Results:

The HA-POL hydrogel transformed from sol to gel at 30°C, close to body temperature, and had stable moisturizing properties. HA-POL hydrogel promoted skin-wound healing and increased protein accumulation in the wound area. HA-POL hydrogel allowed greater air permeability than Band-aid, a typical wound covering. Results from transwell assays showed that the HA-POL hydrogel effectively isolated skin-wounds from bacterial invasion.

Conclusion:

This work demonstrates the advantages of using HA-POL gel materials in the treatment of cutaneous wounds.

KEYWORDS:

HA‐POL hydrogel; hyaluronic acid; poloxamer 407; skin‐wound healing

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