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Cell Biosci. 2019 Jun 26;9:53. doi: 10.1186/s13578-019-0314-y. eCollection 2019.

The single-cell sequencing: new developments and medical applications.

Tang X#1,2, Huang Y#1,2, Lei J1,2, Luo H1,2, Zhu X1,2.

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1The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023 China.
Guangdong Provincial Zhanjiang Bay Key Laboratory, Zhanjiang, 524023 China.
Contributed equally


Single-cell sequencing technologies can be used to detect the genome, transcriptome and other multi-omics of single cells. They can show the differences and evolutionary relationships of various cells. This review introduces the latest advances in single-cell sequencing technologies and their applications in oncology, microbiology, neurology, reproduction, immunology, digestive and urinary systems, highlighting the important role that single-cell sequencing techniques play in these areas.


Cancer; Clinical applications; Developments; Immunology; Single-cell sequencing technologies; Transcriptome

Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

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