The Molecular Architecture of Unnatural Amino Acid Translation Systems

Structure. 2019 Aug 6;27(8):1192-1194. doi: 10.1016/j.str.2019.07.007.

Abstract

Expanding the genetic code using non-canonical amino acids has revolutionized synthetic biology. In a recent issue of Cell Chemical Biology, Yanagisawa et al. (2019) expanded our knowledge of orthogonal translation systems by presenting a tour de force structural characterization of multiple genetic code expansion systems based on pyrrolysyl-tRNA synthetase.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Amino Acids
  • Amino Acyl-tRNA Synthetases*
  • Genetic Code
  • Lysine
  • RNA, Transfer

Substances

  • Amino Acids
  • RNA, Transfer
  • Amino Acyl-tRNA Synthetases
  • Lysine

Grants and funding