Abstract
An all in one nano-system with active-targeting, enzyme-triggered deshielding and positive-charge characteristics was fabricated for chemo/photo-combination therapy to allow efficient tumor targeting, cellular internalization and lysosomal escape. The deshielding of NPs was induced by enzyme triggered degradation of the NP shell, and consequently exposure of the positively charged core accelerates escape of NPs from the lysosome to exert anticancer effects with high efficiency.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / therapeutic use*
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Cell Line, Tumor
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Doxorubicin / therapeutic use
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Drug Carriers / chemistry*
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Drug Carriers / metabolism
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Drug Liberation
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Humans
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Hyaluronan Receptors / metabolism
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Hyaluronic Acid / chemistry
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Hyaluronic Acid / metabolism
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Hyaluronoglucosaminidase / metabolism
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Light
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Lysosomes / metabolism*
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Mice
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Nanoparticles / chemistry*
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Nanoparticles / metabolism
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Neoplasms / drug therapy*
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Photochemotherapy / methods
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Photosensitizing Agents / radiation effects
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Photosensitizing Agents / therapeutic use*
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Polylysine / chemistry
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Protoporphyrins / radiation effects
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Protoporphyrins / therapeutic use
Substances
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Antineoplastic Agents
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Drug Carriers
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Hyaluronan Receptors
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Photosensitizing Agents
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Protoporphyrins
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Polylysine
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Doxorubicin
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Hyaluronic Acid
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protoporphyrin IX
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Hyaluronoglucosaminidase