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Chem Commun (Camb). 2019 Sep 4;55(68):10158-10161. doi: 10.1039/c9cc05545b. Epub 2019 Aug 7.

Heptylmannose-functionalized cellulose for the binding and specific detection of pathogenic E. coli.

Author information

1
Université de Nantes, CEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, UMR CNRS 6230, UFR des Sciences et des Techniques, 2, rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France. sebastien.gouin@univ-nantes.fr.
2
Clermont Université, UMR 1071 Inserm/Université d'Auvergne, 63000 Clermont-Ferrand, France.
3
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF), UMR8576 CNRS, Université de Lille 1, Lille 59000, France.
4
Glycodiag, Bâtiment Physique-Chimie, Rue de Chartres, BP6759, 45067 Orléans cedex 2, France.

Abstract

We developed a chemical method to covalently functionalize cellulose nanofibers and cellulose paper with mannoside ligands displaying a strong affinity for the FimH adhesin from pathogenic E. coli strains. Mannose-grafted cellulose proved efficient to selectively bind FimH lectin and discriminate pathogenic E. coli strains from non-pathogenic ones. These modified papers are valuable tools for diagnosing infections promoted by E. coli, such as cystitis or inflammatory bowel diseases, and the concept may be applicable to other life-threatening pathogens.

PMID:
31389420
DOI:
10.1039/c9cc05545b
[Indexed for MEDLINE]

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