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Curr Drug Targets. 2019 Aug 7. doi: 10.2174/1389450120666190807143245. [Epub ahead of print]

Nanosized Modification Strategies for Improving the Antitumor Efficacy of MEK Inhibitors.

Author information

1
Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, Shanxi, P. R. China.
2
Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Science, Health Science Center, Xi`an Jiaotong University, No.76 Yanta West Road, Xi`an 710061, Shaanxi, P. R. China.
3
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, P. R. China.

Abstract

The RAS-RAF-MEK-ERK signaling pathway (MAPK signaling) is hyperactivated in more than 30% of human cancers. The crucial roles of mitogen-activated protein kinase kinase (MEK) in tumorigenesis, cell proliferation and apoptosis inhibition, make MEK inhibitors (MEKi) attractive candidates for the targeted therapy of cancer as a result of gain-of-function mutations in RAS or RAF genes. Several highly selective and potent non-ATP-competitive allosteric MEKi have been developed and have led to substantial improvements in clinical outcomes. However, the drug efficacies and response rates are limited due to complex pathway cross-talk and pessimistic drug solubility. Nanosized modifications have made great contributions to improving drug efficacies over the past decades. In this review, the important biological status of MEK kinase in the MAPK pathway is illuminated primarily to highlight the irreplaceable position and clinical status of MEKi. In addition, nanomodification strategies to enhance drug efficacy are briefly summarized, followed by the application advances of nanotechnology in the field of MEKi-related cancer theranostics. Finally, the obstacles impeding the development of nanosized MEKi are considered, and promising prospects are suggested. This informative report lays the groundwork for the clinical development of MEKi and outlines a rational frontline-treatment approach for personalized cancer treatment.

KEYWORDS:

MAPK signaling pathway; MEK inhibitor; Nanomedicine; enhanced drug efficacy; modification strategy; targeted cancer theranostics

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