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Pediatr Radiol. 2019 Dec;49(13):1843-1847. doi: 10.1007/s00247-019-04491-5. Epub 2019 Aug 5.

Prenatal evaluation of the Sakoda complex.

Author information

1
Department of Radiology and Medical Imaging, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229, USA. usha.nagaraj@cchmc.org.
2
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. usha.nagaraj@cchmc.org.
3
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
4
Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
5
Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
6
Department of Radiology and Medical Imaging, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229, USA.

Abstract

Sakoda complex is a rare but distinct combination of birth defects consisting of a basal cephalocele, agenesis of the corpus callosum, and midline cleft lip/palate. It has been reported in association with ophthalmologic abnormalities, cognitive deficits and severe epilepsy. Here we describe both prenatal and postnatal MRI findings of a classic case of Sakoda complex in a child with characteristic findings on fetal MRI; prenatal findings have not been described in the literature. Diagnosis of this entity has important implications for prenatal counseling and perinatal management, as is demonstrated in this case.

KEYWORDS:

Basal encephalocele; Fetus; Magnetic resonance imaging; Neonate; Sakoda complex

PMID:
31384970
DOI:
10.1007/s00247-019-04491-5

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