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J Clin Med. 2019 Aug 3;8(8). pii: E1164. doi: 10.3390/jcm8081164.

Efficacy and Safety of Belatacept Treatment in Renal Allograft Recipients at High Cardiovascular Risk-A Single Center Experience.

Author information

1
Department of Internal Medicine IV-Nephrology and Hypertension, Medical University of Innsbruck, Anichstrasse 35, Innsbruck A-6020, Austria. Hannes.Neuwirt@i-med.ac.at.
2
Department of Pharmacology, Section for Molecular and Cellular Pharmacology, Medical University of Innsbruck, Peter-Mayr-Strasse 1a, Innsbruck 6020, Austria.
3
Department of Internal Medicine IV-Nephrology and Hypertension, Medical University of Innsbruck, Anichstrasse 35, Innsbruck A-6020, Austria.
4
Landeskrankenhaus Feldkirch, Department of Internal Medicine III-Nephrology, Carinagasse 47, Feldkirch 6800, Austria.
5
Department of Urology, Medical University of Innsbruck, Anichstrasse 35, Innsbruck A-6020, Austria.

Abstract

Belatacept is an attractive option for immunosuppression after renal transplantation. Renal allograft function is superior when compared to calcineurin inhibitor (CNI) based therapy in "de novo" treated patients and it has also been proposed that individuals at high cardiovascular (CV) risk may benefit most. In this retrospective cohort study, we assessed the efficacy and safety of treating patients at high cardiovascular risk with Belatacept (n = 34, for 1194 observation months) when compared to a matched control group of 150 individuals under CNI immunosuppression (for 7309 months of observation). The estimated glomerular filtration rate (eGFR) increased for patients taking Belatacept but decreased during CNI-based therapy (+2.60 vs. -0.89 mL/min/1.73 m2/year, p = 0.006). In a multivariate Cox regression model, Belatacept remained the only significant factor associated with the improvement of eGFR (HR 4.35, 95%CI 2.39-7.93). Belatacept treatment was not a significant risk factor for renal allograft rejection or graft loss. In terms of safety, the only significant risk factor for de novo cardiovascular events was a pre-existing cerebrovascular disease, but Belatacept was not associated with a significant risk reduction. Belatacept treatment was not associated with an increased risk of severe infections, cytomegalo virus (CMV) or BK-virus reactivation, malignancy or death in the multivariate Cox regression analysis. Belatacept is an efficient and safe option for patients after renal transplantation at high cardiovascular risk.

KEYWORDS:

Belatacept; cardiovascular high risk; kidney transplantation; outcome

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