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Org Lett. 2019 Aug 16;21(16):6275-6279. doi: 10.1021/acs.orglett.9b02159. Epub 2019 Aug 5.

Madurastatin D1 and D2, Oxazoline Containing Siderophores Isolated from an Actinomadura sp.

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Pharmaceutical Sciences Division , University of Wisconsin-Madison , 777 Highland Avenue , Madison , Wisconsin 53705 , United States.
Department of Genetics , University of Wisconsin-Madison , 425 G Henry Mall , Madison , Wisconsin 53706 , United States.
Department of Bacteriology , University of Wisconsin-Madison , 1550 Linden Avenue , Madison , Wisconsin 53706 , United States.
Department of Medicinal Chemistry , University of Utah , 30 South 2000 East , Salt Lake City , Utah 84112 , United States.


Two new siderophores, madurastatin D1 and D2, together with (-)-madurastatin C1, the enantiomer of a known compound, were isolated from marine-derived Actinomadura sp. The presence of an unusual 4-imidazolidinone ring in madurastatins D1 and D2 inspired us to sequence the Actinomadura sp. genome and to identify the mad biosynthetic gene cluster, knowledge of which enables us to now propose a biosynthetic pathway. Madurastatin D1 and D2 are moderately active in antimicrobial assays with M. luteus.

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