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Trends Endocrinol Metab. 2019 Sep;30(9):569-571. doi: 10.1016/j.tem.2019.07.017. Epub 2019 Jul 31.

Reconstitution of Organismal Liver Clock Function Requires Light.

Author information

1
Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyō-ku, Kyoto 606-8501, Japan.
2
Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyō-ku, Kyoto 606-8501, Japan. Electronic address: doimasao@pharm.kyoto-u.ac.jp.

Abstract

Recently Koronowski et al. (Cell, 2019) showed that reconstitution of the liver circadian clock in otherwise genetically arrhythmic mice revives the daily program of the nicotinamide adenine dinucleotide salvage pathway and glycogenesis in vivo. This liver-autonomous metabolic cycling cannot be sustained under constant darkness, revealing the importance of the daily light cycle to restore liver function.

KEYWORDS:

Bmal1; autonomy; circadian; diurnal physiology; light; liver metabolism; systemic signaling

PMID:
31375394
DOI:
10.1016/j.tem.2019.07.017

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