Send to

Choose Destination
Mar Drugs. 2019 Aug 1;17(8). pii: E455. doi: 10.3390/md17080455.

Long-Chain Bases from Sea Cucumber Alleviate Obesity by Modulating Gut Microbiota.

Author information

Innovation Application Institute, Zhejiang Ocean University, Zhoushan 316022, China.
Wenzhou Academy of Agricultural Sciences, Wenzhou 325006, China.
College of Food Science, Qingdao University, Qingdao 266071, China.
Wenzhou Academy of Agricultural Sciences, Wenzhou 325006, China.
Zhejiang Marine Development Research Institute, Zhoushan 316021, China.


This study evaluated the effects of long-chain bases from sea cucumber (SC-LCBs) on modulation of the gut microbiota and inhibition of obesity in high fat diet-fed mice. Results showed that SC-LCBs exerted significant antiobese effects, which were associated with the inhibition of hyperglycemia and lipid accumulation. SC-LCBs also regulated serum adipocytokines toward to normal levels. SC-LCBs caused significant decreases in Firmicutes, Actinobacteria phylum, and obesity-related bacteria (Desulfovibro, Bifidobacterium, Romboutsia etc. genus). SC-LCBs also elevated Bacteroidetes, Proteobacteria, Verrucomicrobia phylum, and short chain fatty acids (SCFAs)-producing bacteria (Bacteroides, Lactobacillus, Lachnospiraceae_NK4A136_group etc. genus). Moreover, serum and fecal lipoplysaccharide (LPS) concentrations and its dependent toll-line receptor 4 pathway were inhibited by SC-LCBs treatment. SC-LCBs caused increases in fecal SCFAs and their mediated G-protein-coupled receptors proteins. These suggest that SC-LCBs alleviate obesity by altering gut microbiota. Thus, it sought to indicate that SC-LCBs can be developed as food supplement for the obesity control and the human gut health.


gut microbiota; lipopolysaccharide; long-chain bases; obesity; sea cucumber; short chain fatty acids

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center