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Bioinformatics. 2019 Aug 2. pii: btz614. doi: 10.1093/bioinformatics/btz614. [Epub ahead of print]

PIRD: Pan immune repertoire database.

Zhang W1,2, Wang L1,2,3, Liu K1,2, Wei X1,2, Yang K1,2, Du W1,2, Wang S1,2,3, Guo N1,2, Ma C1,2, Luo L1,2, Wu J1,2, Lin L1,2, Yang F1,2, Gao F1,2, Wang X1,2, Li T1,2, Zhang R1,2, Saksena NK1,2, Yang H1,4, Wang J1,4, Fang L1,5, Hou Y1,2, Xu X1,2, Liu X1,2.

Author information

1
BGI-Shenzhen, Shenzhen, China.
2
China National GeneBank, BGI-Shenzhen, Shenzhen, China.
3
BGI-Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
4
James D. Watson Institute of Genome Sciences, Hangzhou, China.
5
Department of Biology, University of Copenhagen, Copenhagen, Denmark.

Abstract

MOTIVATION:

T and B cell receptors (TCRs and BCRs) play a pivotal role in the adaptive immune system by recognizing an enormous variety of external and internal antigens. Understanding these receptors is critical for exploring the process of immunoreaction and exploiting potential applications in immunotherapy and antibody drug design. Although a large number of samples have had their TCR and BCR repertoires sequenced using high-throughput sequencing in recent years, very few databases have been constructed to store these kinds of data. To resolve this issue, we developed a database.

RESULTS:

We developed a database, the Pan Immune Repertoire Database (PIRD), located in China National GeneBank (CNGBdb), to collect and store annotated TCR and BCR sequencing data, including from Homo sapiens and other species. In addition to data storage, PIRD also provides functions of data visualisation and interactive online analysis. Additionally, a manually curated database of TCRs and BCRs targeting known antigens (TBAdb) was also deposited in PIRD.

AVAILABILITY AND IMPLEMENTATION:

PIRD can be freely accessed at https://db.cngb.org/pird.

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