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J Vet Intern Med. 2019 Aug 2. doi: 10.1111/jvim.15561. [Epub ahead of print]

Clinical utility of estimation of glomerular filtration rate in dogs.

Author information

1
Department of Clinical Science and Services, Royal Veterinary College, London, United Kingdom.
2
Department of Comparative Biomedical Sciences, Royal Veterinary College, London, United Kingdom.
3
Anderson Moores Veterinary Specialists, Winchester, United Kingdom.

Abstract

BACKGROUND:

Glomerular filtration rate (GFR) estimation is the gold standard for assessment of renal function, although the clinical utility of this test is unclear.

OBJECTIVES:

To describe the clinical utility of GFR estimation in dogs.

ANIMALS:

Medical records of 132 dogs that had serum iohexol clearance measured between 2012 and 2017.

METHODS:

Iohexol clearance and clinical records were reviewed and submitting practices contacted to obtain outcome data. Dogs were classified into 4 groups based on the reason for performing GFR estimation: A1 (screening for pre-azotemic chronic kidney disease [CKD], n = 105), A2 (confirmation of azotemic CKD, n = 3), B (screening for pre-azotemic acute kidney injury, n = 19), and C (miscellaneous causes, n = 5). Descriptive review of the clinical utility of GFR estimation is provided.

RESULTS:

For dogs in Group A1, renal disease was diagnosed in 9/9 dogs with a GFR ≥40% decreased below the mean GFR of their body weight category, in 5/6 dogs with a ≥30% but <40% reduction in GFR and in 7/9 dogs with a ≥20% but <30% reduction in GFR.

CONCLUSIONS AND CLINICAL IMPORTANCE:

Glomerular filtration rate estimation is useful for the diagnosis of CKD before the onset of azotemia.

KEYWORDS:

canine; diagnosis; iohexol clearance; renal

PMID:
31373414
DOI:
10.1111/jvim.15561
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