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Future Microbiol. 2019 Jul;14:839-846. doi: 10.2217/fmb-2018-0299. Epub 2019 Aug 2.

Candida albicans vaginitis in a murine model is reduced by polypeptide-enriched Gastrodia elata extracts.

Author information

1
School of Life Sciences, Jilin University, Changchun, 130012, Jilin Province, China.
2
Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, 130006, Jilin Province, China.

Abstract

Aim: The primary objective of this study was to evaluate the effects of polypeptide-enriched Gastrodia elata extracts (GE) on vulvovaginal candidiasis (VVC). Materials & methods: A VVC model induced by Candida albicans (C. albicans) infection was successfully developed in BALB/c mice. After treatment, the colony-forming unit (CFU) of vaginal lavage was measured by plating. The extent of the inflammatory response was assessed by hematoxylin-eosin (H&E) staining and enzyme-linked immunosorbent assay (ELISA). Results: GE had an inhibitory effect on the proliferation of C. albicans and inflammatory reaction. Meanwhile, it had a potentially beneficial effect on the growth of Lactobacillus. Conclusion: These results showed the potential application of GE as an antifungal agent in VVC treatment.

KEYWORDS:

; antifungal activity; inflammation; polypeptide-enriched extracts; vulvovaginal candidiasis

PMID:
31373210
DOI:
10.2217/fmb-2018-0299

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