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Infect Immun. 1988 Sep;56(9):2515-7.

Measurement of Pseudomonas aeruginosa phenazine pigments in sputum and assessment of their contribution to sputum sol toxicity for respiratory epithelium.

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  • 1Department of Thoracic Medicine, Brompton Hospital, London, United Kingdom.

Abstract

The phenazine pigments pyocyanin and 1-hydroxyphenazine were resolved by high-pressure liquid chromatography from the sputum sol phase from 9 of 13 patients with cystic fibrosis or bronchiectasis colonized by Pseudomonas aeruginosa. The concentrations measured were each sufficient to inhibit ciliary beating in vitro and contributed a significant proportion of sol phase toxicity for respiratory epithelium.

PMID:
3137173
PMCID:
PMC259599
[PubMed - indexed for MEDLINE]
Free PMC Article
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