Format

Send to

Choose Destination
Diabetes Care. 2019 Aug 1. pii: dc190937. doi: 10.2337/dc19-0937. [Epub ahead of print]

The Impact of Sotagliflozin on Renal Function, Albuminuria, Blood Pressure, and Hematocrit in Adults With Type 1 Diabetes.

Author information

1
Diabetes Center, Internal Medicine, Amsterdam UMC, Location VUmc, Amsterdam, the Netherlands.
2
Division of Nephrology, Department of Medicine, and Section of Endocrinology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
3
Steno Diabetes Center Copenhagen, Copenhagen, Denmark.
4
Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
5
Sanofi, Bridgewater, NJ.
6
The George Institute for Global Health, Sydney, Australia.
7
Department of Clinical Pharmacy and Pharmacology, University of Groningen, Groningen, the Netherlands.
8
Division of Nephrology, University of Toronto, Toronto, Canada david.cherney@uhn.ca.

Abstract

OBJECTIVE:

In people with type 2 diabetes, sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce cardiovascular risk and progression of diabetic kidney disease. Our aim was to determine whether sotagliflozin (SOTA), a dual SGLT1i and SGLT2i, had favorable effects on clinical biomarkers suggestive of kidney protection in adults with type 1 diabetes.

RESEARCH DESIGN AND METHODS:

In this 52-week pooled analysis, 1,575 adults enrolled in the inTandem1 and inTandem2 trials were randomized to SOTA 200 mg, 400 mg, or placebo in addition to optimized insulin therapy. Changes in cardiorenal biomarkers were assessed.

RESULTS:

At 52 weeks, in response to SOTA 200 and 400 mg, the placebo-corrected least squares mean change from baseline in estimated glomerular filtration rate was -2.0 mL/min/1.73 m2 (P = 0.010) and -0.5 mL/min/1.73 m2 (P = 0.52), respectively. Systolic blood pressure difference was -2.9 and -3.6 mmHg (P < 0.0001 for both); diastolic blood pressure changed by -1.4 (P = 0.0033) and -1.6 mmHg (P = 0.0008). In participants with baseline urinary albumin-to-creatinine ratio (UACR) ≥30 mg/g, UACR decreased by 23.7% (P = 0.054) and 18.3% (P = 0.18) for SOTA 200 and SOTA 400 mg, respectively, vs. placebo. Increases in serum albumin and hematocrit and reductions in uric acid were observed throughout 52 weeks with both SOTA doses.

CONCLUSIONS:

SOTA was associated with short- and long-term renal hemodynamic changes, which were similar to those seen with SGLT2i in type 2 diabetes. Further investigation around cardiorenal effects of SOTA in people with type 1 diabetes is justified.

PMID:
31371432
DOI:
10.2337/dc19-0937

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center