Format

Send to

Choose Destination
J Am Coll Cardiol. 2019 Aug 6;74(5):683-698. doi: 10.1016/j.jacc.2019.04.068.

From ACE Inhibitors/ARBs to ARNIs in Coronary Artery Disease and Heart Failure (Part 2/5).

Author information

1
The Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada. Electronic address: Darryl.Leong@phri.ca.
2
British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
3
The Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.

Abstract

The pharmacological inhibition of the renin-angiotensin-aldosterone system as a therapeutic strategy is one of the most significant advances in the treatment and prevention of cardiovascular disease in heart failure with reduced ejection fraction and in coronary artery disease. Recently, the addition of neprilysin inhibition to angiotensin receptor blockade has been shown to be even more effective than angiotensin-converting enzyme inhibition alone in heart failure with reduced ejection fraction, marking an important new milestone in heart failure treatment. This review summarizes the major trials that have informed the clinical role of inhibition of the renin-angiotensin-aldosterone and neprilysin pathways, as well as the limitations of these strategies.

KEYWORDS:

ACE-I; ARB; ARNI; coronary disease; heart failure

PMID:
31370961
DOI:
10.1016/j.jacc.2019.04.068

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center