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Nano Lett. 2019 Sep 11;19(9):6244-6254. doi: 10.1021/acs.nanolett.9b02296. Epub 2019 Aug 8.

Selective Formation of Porous Pt Nanorods for Highly Electrochemically Efficient Neural Electrode Interfaces.

Author information

1
Department of Electrical and Computer Engineering , University of California San Diego La Jolla , California 92093 , United States.
2
Department of Neurology , Massachusetts General Hospital , Boston , Massachusetts 02114 , United States.
3
Materials Science and Engineering Program , University of California San Diego , La Jolla , California 92093 , United States.
4
Department of Neurosciences , University of California San Diego , La Jolla , California 92093 , United States.
5
Department of Anesthesiology , University of California, San Diego (UCSD) , La Jolla , California 92037 , United States.
6
Department of Neurosurgery , Massachusetts General Hospital , Boston , Massachusetts 02114 , United States.
7
Departments of Radiology and Neurosciences , University of California San Diego , La Jolla , California 92093 , United States.
8
Department of Neurosurgery , University of California, San Diego (UCSD) , La Jolla , California 92037 , United States.
9
Boston VA Healthcare System , 150 South Huntington Avenue , Boston , Massachusetts 02130 , United States.
10
Department of Nanoengineering , University of California San Diego , La Jolla , California 92093 , United States.

Abstract

The enhanced electrochemical activity of nanostructured materials is readily exploited in energy devices, but their utility in scalable and human-compatible implantable neural interfaces can significantly advance the performance of clinical and research electrodes. We utilize low-temperature selective dealloying to develop scalable and biocompatible one-dimensional platinum nanorod (PtNR) arrays that exhibit superb electrochemical properties at various length scales, stability, and biocompatibility for high performance neurotechnologies. PtNR arrays record brain activity with cellular resolution from the cortical surfaces in birds and nonhuman primates. Significantly, strong modulation of surface recorded single unit activity by auditory stimuli is demonstrated in European Starling birds as well as the modulation of local field potentials in the visual cortex by light stimuli in a nonhuman primate and responses to electrical stimulation in mice. PtNRs record behaviorally and physiologically relevant neuronal dynamics from the surface of the brain with high spatiotemporal resolution, which paves the way for less invasive brain-machine interfaces.

KEYWORDS:

brain; clinical; neural interface; neurotechnology; platinum nanorod

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