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Mol Nutr Food Res. 2019 Aug 1:e1900126. doi: 10.1002/mnfr.201900126. [Epub ahead of print]

Increased Dairy Products Intake Alters Serum Metabolite Profiles in Subjects at Risk of Developing Type 2 Diabetes.

Author information

1
S. O'Connor, K. Greffard, M. Leclercq, P. Julien, S. J. Weisnagel, C. Gagnon, A. Droit, J.-F. Bilodeau, I. Rudkowska, Endocrinology and Nephrology Unit, CHU de Québec-Université Laval Research Center, Québec, Canada.
2
S. O'Connor, I. Rudkowska, Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.
3
M. Leclercq, A. Droit, Department of Molecular Medicine, Faculty of Medicine, Université Laval, Québec, Canada.
4
P. Julien, S. J. Weisnagel, C. Gagnon, J.-F. Bilodeau, Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada.

Abstract

SCOPE:

Metabolomics is increasingly used to identify biomarkers of dietary intake or chronic diseases, such as type 2 diabetes. Yet, metabolite signatures following dairy intake in hyperinsulinemic subjects have not been identified. The objective was to evaluate the effects of a high dairy diet (HD) for 6 weeks (≥4 servings/day), compared with an adequate dairy diet (AD) (≤2 servings/day), on serum metabolite profiles in hyperinsulinemic adults.

METHODS AND RESULTS:

In this crossover trial, subjects were randomized to HD or AD for 6 weeks. Serum metabolites were assessed using GC/MS. Twenty-six subjects completed the study (age: 55 ± 14 years, BMI: 31 ± 3 kg/m2 (mean±SD)). Results showed that levels of pentadecanoic acid (p = 0.04), tyrosine (p = 0.009) and lathosterol (p = 0.03) were increased in HD, while 1,5-anhydrosorbitol (p = 0.02), myo-inositol (p = 0.04), 3-aminoisobutyric acid (p = 0.002) and beta-sitosterol (p = 0.01) were decreased. Sorbitol levels were increased after AD (p = 0.03), while hexanoic acid, lauric acid, L-kynurenine, methionine and benzoic acid levels were reduced (p<0.05). Histidine, caprylic acid, nonanoic acid, decanoic acid, lauric acid, heptadecanoic acid and benzoic acid levels were increased in HD compared to AD, while changes in malic acid were increased in AD compared to HD (p<0.05).

CONCLUSION:

Higher dairy products intake modifies metabolite profiles in hyperinsulinemic subjects. This article is protected by copyright. All rights reserved.

KEYWORDS:

GC/MS; biomarker; hyperinsulinemia; metabolite profiling; milk; prediabetes

PMID:
31368661
DOI:
10.1002/mnfr.201900126

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