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Curr Psychiatry Rep. 2019 Aug 1;21(8):78. doi: 10.1007/s11920-019-1062-8.

Obsessive-Compulsive Disorder: Autoimmunity and Neuroinflammation.

Author information

1
Inserm U955, Team 15, Genetic Psychiatry, 94000, Creteil, France.
2
AP-HP, DHU Pe-PSY, Henri Mondor - Albert Chenevier, group, Psychiatry, 94000, Creteil, France.
3
Faculté de médecine, UPEC, Université Paris-Est, 94000, Créteil, France.
4
Inserm U955, Team 15, Genetic Psychiatry, 94000, Creteil, France. nora.hamdani@aphp.fr.
5
AP-HP, DHU Pe-PSY, Henri Mondor - Albert Chenevier, group, Psychiatry, 94000, Creteil, France. nora.hamdani@aphp.fr.

Abstract

PURPOSE OF REVIEW:

Here, we propose to review the immuno-inflammatory hypothesis in OCD given the concurrent incidence of autoimmune comorbidities, infectious stigma, and raised levels of inflammatory markers in a significant subset of patients. A better understanding of the immune dysfunction in OCD may allow stratifying the patients in order to design personalized pharmaco/psychotherapeutic strategies.

RECENT FINDINGS:

A persistent low-grade inflammation involving both innate and adaptive immune system with coexisting autoimmune morbidities and stigma of infectious events has been prominently observed in OCD. Hence, specific treatments targeting inflammation/infection are a feasible alternative in OCD. This review highlights that OCD is associated with low-grade inflammation, neural antibodies, and neuro-inflammatory and auto-immune disorders. In some subset of OCD patients, autoimmunity is likely triggered by specific bacterial, viral, or parasitic agents with overlapping surface epitopes in CNS. Hence, subset-profiling in OCD is warranted to benefit from distinct immune-targeted treatment modalities.

KEYWORDS:

Autoimmunity; Infections; Inflammation; OCD

PMID:
31367805
DOI:
10.1007/s11920-019-1062-8

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