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J Conserv Dent. 2019 May-Jun;22(3):237-240. doi: 10.4103/JCD.JCD_19_19.

In vitro comparison of apical microleakage by spectrophotometry in simulated apexification using White Mineral Trioxide Aggregate, TotalFill Bioceramic Root Repair material, and BioDentine.

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Department of Endodontics, University of Barcelona, Barcelona, IDIBELL Institute, Barcelona, Spain.



The purpose of this study was to compare the sealing ability of various calcium silicate-based root-filling materials with a glucose leakage model after orthograde obturation using an open apex model.

Materials and Methods:

Thirty-two recently extracted human maxillary anterior teeth with single, straight root canals were selected and divided into four groups: Group 1 (G1), White Mineral Trioxide Aggregate; the material was delivered into the canal using the MAP system and further compacted with a specific plugger. Group 2 (G2), TotalFill bioceramic Root Repair material: the material was injected directly into the middle half of the root canal. Group 3 (G3), BioDentine; the material was delivered into the canal using the Hawe composite gun and prefitted pluggers.

Statistical Analysis:

Statistical analysis was performed using the SPSS 23.0 statistical software package. The Kruskal-Wallis nonparametric test was applied to compare the differences in glucose microleakage.


There were no significant differences among the three experimental groups. The results showed a tendency for leakage to increase from the 1st day to the end of experimental period.


Within the parameters of this in vitro study, it may be concluded that the three materials evaluated present similar apical microleakage when treating teeth with open apices requiring orthograde delivery of an apical barrier.


Apexification; Mineral Trioxide Aggregate; apical microleakage; bioceramic cements

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