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Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):18068-18077. doi: 10.1073/pnas.1906595116. Epub 2019 Jul 31.

Rapid and active stabilization of visual cortical firing rates across light-dark transitions.

Author information

1
Department of Biology, Brandeis University, Waltham, MA 02453.
2
Computation in Neural Circuits Group, Max Planck Institute for Brain Research, 60438 Frankfurt, Germany.
3
School of Life Sciences, Technical University of Munich, 85354 Freising, Germany.
4
Department of Biology, Brandeis University, Waltham, MA 02453; turrigiano@brandeis.edu.

Abstract

The dynamics of neuronal firing during natural vision are poorly understood. Surprisingly, mean firing rates of neurons in primary visual cortex (V1) of freely behaving rodents are similar during prolonged periods of light and darkness, but it is unknown whether this reflects a slow adaptation to changes in natural visual input or insensitivity to rapid changes in visual drive. Here, we use chronic electrophysiology in freely behaving rats to follow individual V1 neurons across many dark-light (D-L) and light-dark (L-D) transitions. We show that, even on rapid timescales (1 s to 10 min), neuronal activity was only weakly modulated by transitions that coincided with the expected 12-/12-h L-D cycle. In contrast, a larger subset of V1 neurons consistently responded to unexpected L-D and D-L transitions, and disruption of the regular L-D cycle with 60 h of complete darkness induced a robust increase in V1 firing on reintroduction of visual input. Thus, V1 neurons fire at similar rates in the presence or absence of natural stimuli, and significant changes in activity arise only transiently in response to unexpected changes in the visual environment. Furthermore, although mean rates were similar in light and darkness, pairwise correlations were significantly stronger during natural vision, suggesting that information about natural scenes in V1 may be more strongly reflected in correlations than individual firing rates. Together, our findings show that V1 firing rates are rapidly and actively stabilized during expected changes in visual input and are remarkably stable at both short and long timescales.

KEYWORDS:

firing-rate stability; rodent vision; visual cortex; visual experience

PMID:
31366632
PMCID:
PMC6731644
DOI:
10.1073/pnas.1906595116
[Indexed for MEDLINE]
Free PMC Article

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