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Anticancer Res. 2019 Aug;39(8):4503-4509. doi: 10.21873/anticanres.13626.

Preventive Effect of Oral Administration of Pantoea agglomerans-derived LPS in a Hypertensive Rat Model Upon Salt Loading.

Author information

1
R&D Division, Control of Innate Immunity, Technology Research Association, Kagawa, Japan zhang@shizenmeneki.org.
2
R&D Division, Umeken CO., LTD, Osaka, Japan.
3
R&D Division, Control of Innate Immunity, Technology Research Association, Kagawa, Japan.
4
Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
5
Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Abstract

BACKGROUND/AIM:

Oral administration of Pantoea agglomerans-derived lipopolysaccharide (LPSp) has been reported to have a preventive effect against various lifestyle-related diseases. Therefore, we examined the preventive effect on high blood pressure, which is a kind of reserve arm for lifestyle-related diseases.

MATERIALS AND METHODS:

Spontaneous hypertensive rat (SHR) and WKY rat were bred from 6 to 16 weeks of age. SHR were orally administered 100 μg/kg LPSp and 0.1% NaCl, and blood pressure was measured at 6, 10, 13 and 16 weeks. Furthermore, at 16 weeks of age, blood biochemical markers were measured and microbial community composition was analyzed.

RESULTS:

SHRs developed hypertension with age, which was exacerbated by salt loading. Although there was almost no reduction in blood pressure in SHRs that received LPSp. It was suppressed at 13-16 weeks of age in those with salt loading.

CONCLUSION:

Oral administration of LPSp showed a preventive effect on salt-loaded hypertension.

KEYWORDS:

Hypertensive; Pantoea agglomerans-derived LPS; oral administration; salt loading

PMID:
31366552
DOI:
10.21873/anticanres.13626
[Indexed for MEDLINE]

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