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Anticancer Res. 2019 Aug;39(8):4227-4236. doi: 10.21873/anticanres.13584.

Left Ventricular Speckle Tracking Echocardiography Changes Among Early-stage Breast Cancer Patients Three Years After Radiotherapy.

Author information

1
Heart and Lung Center, Helsinki University Central Hospital and Helsinki University, Helsinki, Finland suvi.tuohinen@fimnet.fi.
2
Faculty of Medicine and Life Sciences, Tampere University Hospital, University of Tampere and Heart Center, Tampere, Finland.
3
Department of Oncology, Tampere University Hospital, Tampere, Finland.
4
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
5
Faculty of Social Sciences, University of Tampere, Tampere, Finland.
6
Heart and Lung Center, Helsinki University Central Hospital and Helsinki University, Helsinki, Finland.

Abstract

BACKGROUND/AIM:

Chest radiotherapy (RT) doubles late cardiac mortality. This study aimed to evaluate the evolution of cardiac changes in speckle tracking echocardiography during a three-year follow-up.

MATERIALS AND METHODS:

This prospective study included 81 chemotherapy-naïve early-stage breast cancer patients who were evaluated at baseline, immediately after RT and three years after RT. Sixty-one patients had left-sided (LSBC) and 20 right-sided breast cancer (RSBC).

RESULTS:

Global longitudinal strain (GLS) declined from baseline -18.0±3.3% to -17.0±3.0% (p=0.015) at the three-year follow-up examination. A decline over 15% (GLS15) was observed in 19 (27%) patients. GLS15 was independently associated with aromatase inhibitor use (β=-1.977, p=0.001). In regional analysis, patients with LSBC had apical strain decline by 3.2±5.5% (p<0.001) and patients with RSBC showed basal rotation decline by 1.8° (-0.2°, 3.8°) (p=0.030).

CONCLUSION:

Even contemporary RT induced progressive global and regional decline in speckle tracking analysis. The regional changes complied with RT fields.

KEYWORDS:

Breast cancer; midterm follow-up; radiotherapy; speckle tracking echocardiography

PMID:
31366510
DOI:
10.21873/anticanres.13584
[Indexed for MEDLINE]

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